Lecturer at Bangor University. Working on phages. Art commissions. redbubble.com/people/Jellie ellie__jameson@mastodon.online @elliejameson.bsky.social
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#microber2022 #inktober2022 31 Spooky: nothing more spooky than a multi drug resistant bacteria, unless you are one, … then maybe a phage? #SciArt #AMR
#microber2023 #inktober2022 Light: phage therapy offers a “light at the end of the tunnel” when faced with the antibiotic apocalypse. Phages can treat and kill these potentially life-threatening antimicrobial-resistant infections and save lives. #SciArt #phage
#microber2022 #inktober2022 Soil: viruses, particularly phages, play a vital role in soil functioning, which is still being uncovered. I took inspiration from the near universal photo for soil: a pair of clean hands delicately cupping it in the shape of a heart! #SciArt twitter.com/Ellie__James…
#microber2022 #inktober2022 Roots: as roots grow they provide a new environment that shapes the microbial community, and root exudates provide food for this community. Not forgetting the #phages which provide a vital role in shaping the function of the community. #SciArt
#microber2022 #inktober2022 Protect: bacteria have a whole host of systems such as CRISPR-Cas to protect them from bacteriophage infections. An individual bacterium is unlikely to carry all the different options as it would be too great a burden. #SciArt #Phage
#microber2022 #inktober2022 19 Ocean: every drop off water from the ocean is full of bacteriophages, ~250 million per ml! They outnumber bacterial cells 10:1. #SciArt #phage
#Microber2022 #inktober2022 18 Metal: metal ions such as calcium or magnesium chloride can be crucial to phage-host binding and hence reproduction. Forgetting the metal can lead to really disappointing results. #phage #SciArt
@lesliemolson Thank you for the retweet! I research the unseen majority (microbes, particularly bacteriophages). It is fantastic to be able to reach a new audience through art and make people aware of the beauty and ingenuity of these tiny microbes #Microber #inktober #LeslieMolsonOber
#Microber2022 #inktober2022 Phase: crAssphage are lytic phages that infect bacteria in the human gut. They only infect at certain phases of their host’s growth, reproduce slowly, and stably persist alongside their hosts. bmcbiol.biomedcentral.com/articles/10.11…
#microber2022 #inktober2022 14 Community: understanding microbial communities through sequencing, effort is focused on bacteria and their functions. Viruses (inc phages), fungi, etc are overlooked, but #phage are vitally important in shaping communities and functions #SciArt
#microber2022 #inktober2022 13 DNA: phage’s heads are packed with nucleic acid (DNA or RNA), the blueprints for making new phages. CryoEM can allow the DNA structures to be visualised. #SciArt #Phage
#microber2022 #inktober2022 12 Parasitic: a parasite of a Human parasite can be used as an important treatment. Phage therapy has the potential to treat antibacterial resistant bacterial infections which can’t be killed by antibiotics alone. #SciArt #Phage
#microber2022 #inktober2022 Grow: soil microbiomes and viromes grow and develop with the plants they interact with. The amazing work of my PhD student @GMuscatt has shown that repeated growth of the same crop primes the viruses present doi.org/10.1101/2022.0…
#microber2022 #inktober2022 10 Time: time is critical for phage infection and successful proliferation. This could be because phages can only infect at a certain the growth stage, point in the diel cycle or prior to biofilm formation doi.org/10.1016/j.biof… #SciArt #Phage
#Microber2022 #inktober2022 Sleep: while phages don’t actually sleep, when there are no bacterial hosts around they are inert 💤 . Phages can be stored in a dark fridge for years, just waiting for a bacteria to come along so they can “wake up” and reproduce #SciArt #Phage
#Microber2022 #inktober2022 7 Transform: to manipulate bacteria they are transformed by adding DNA that codes for a function of interest. Transforming phage is more complex, firstly the DNA is added to a host bacterium, which is infected with the #phage #SciArt
#Microber2022 #inktober2022 5 Ferment: fermented foods and drinks rely on microbes including yeast and bacteria to preserve and add flavour. #SciArt
#PortfolioDay I'm Ellie and I like drawing microbes, particularly bacteria and #phage! #SciArt
Monstrous #Microber2021 #inktober2021 bacteria exposed to antibiotics can become “superbugs” maybe not quite as monstrous as this Kaiju bacteria, but a serious threat to the health care system worldwide #AMRcomic @MireilleLCB
Adhesion #Microber2021 #inktober2021 phages recognise and bind to host receptors, then irreversibly bind to inject their genomic material into the host to replicate #phage #SciArt
Strain #Microber2021 #inktober2021 there are many different strains of Klebsiella pneumoniae. They are classed as the same species, but show some genetic differences. This can be in the capsule genes that protect them from antibiotics and some phages #SciArt #phage
Competition #Microber2021 #inktober2021 when a prophage or phage infects a bacterial cell it can prevent secondary phage infection by a new incoming phage (superinfection exclusion) #SciArt #Phageink
Splat #inktober2021 #Microber2021 on holiday so no time for an ink sketch, but progress on the #AMRcomic, in collaboration with @MireilleLCB #SciArt
Extinct #Inktober2021 #Microber2021 Phages tend not to make any one bacteria extinct. Those more abundant bacteria are more likely to be targets in “kill the winner” dynamics. This promotes bacterial diversity and prevents any one bacteria dominating #WorldPhageWeek #SciArt
