#microber2023 #inktober2022 Light: phage therapy offers a “light at the end of the tunnel” when faced with the antibiotic apocalypse. Phages can treat and kill these potentially life-threatening antimicrobial-resistant infections and save lives. #SciArt #phage
#microber2022 #inktober2022 Soil: viruses, particularly phages, play a vital role in soil functioning, which is still being uncovered. I took inspiration from the near universal photo for soil: a pair of clean hands delicately cupping it in the shape of a heart! #SciArt twitter.com/Ellie__James…
#microber2022 #inktober2022 Roots: as roots grow they provide a new environment that shapes the microbial community, and root exudates provide food for this community. Not forgetting the #phages which provide a vital role in shaping the function of the community. #SciArt
#microber2022 #inktober2022 Protect: bacteria have a whole host of systems such as CRISPR-Cas to protect them from bacteriophage infections. An individual bacterium is unlikely to carry all the different options as it would be too great a burden. #SciArt #Phage
#Microber2022 #inktober2022 18 Metal: metal ions such as calcium or magnesium chloride can be crucial to phage-host binding and hence reproduction. Forgetting the metal can lead to really disappointing results. #phage #SciArt
@lesliemolson Thank you for the retweet! I research the unseen majority (microbes, particularly bacteriophages). It is fantastic to be able to reach a new audience through art and make people aware of the beauty and ingenuity of these tiny microbes #Microber #inktober #LeslieMolsonOber
#Microber2022 #inktober2022 Phase: crAssphage are lytic phages that infect bacteria in the human gut. They only infect at certain phases of their host’s growth, reproduce slowly, and stably persist alongside their hosts. bmcbiol.biomedcentral.com/articles/10.11…
#microber2022 #inktober2022 14 Community: understanding microbial communities through sequencing, effort is focused on bacteria and their functions. Viruses (inc phages), fungi, etc are overlooked, but #phage are vitally important in shaping communities and functions #SciArt
#microber2022 #inktober2022 Grow: soil microbiomes and viromes grow and develop with the plants they interact with. The amazing work of my PhD student @GMuscatt has shown that repeated growth of the same crop primes the viruses present doi.org/10.1101/2022.0…
#microber2022 #inktober2022 10 Time: time is critical for phage infection and successful proliferation. This could be because phages can only infect at a certain the growth stage, point in the diel cycle or prior to biofilm formation doi.org/10.1016/j.biof… #SciArt #Phage
#Microber2022 #inktober2022 7 Transform: to manipulate bacteria they are transformed by adding DNA that codes for a function of interest. Transforming phage is more complex, firstly the DNA is added to a host bacterium, which is infected with the #phage #SciArt
#Microber2022 #inktober2022 5 Ferment: fermented foods and drinks rely on microbes including yeast and bacteria to preserve and add flavour. #SciArt
#PortfolioDay I'm Ellie and I like drawing microbes, particularly bacteria and #phage! #SciArt
Monstrous #Microber2021 #inktober2021 bacteria exposed to antibiotics can become “superbugs” maybe not quite as monstrous as this Kaiju bacteria, but a serious threat to the health care system worldwide #AMRcomic @MireilleLCB
Adhesion #Microber2021 #inktober2021 phages recognise and bind to host receptors, then irreversibly bind to inject their genomic material into the host to replicate #phage #SciArt
Strain #Microber2021 #inktober2021 there are many different strains of Klebsiella pneumoniae. They are classed as the same species, but show some genetic differences. This can be in the capsule genes that protect them from antibiotics and some phages #SciArt #phage
Splat #inktober2021 #Microber2021 on holiday so no time for an ink sketch, but progress on the #AMRcomic, in collaboration with @MireilleLCB #SciArt
Leak #inktober2021 #Microber2021 sometimes host DNA leaks into new phage particles during packaging and can lead to horizontal gene transfer #SciArt #Phage #WorldPhageWeek
Persistence #Microber2021 #WorldPhageDay #Inktober Phages can persist for a long time if protected from UV light. I have some in the fridge I isolated 15 years ago no special storage but they are still viable (I need to do something with them!). Other phages degrade faster
Sprout #inktober2021 #Microber2021 phages can be used to prevent disease-causing bacteria growing on food like Alfalfa sprouts which have been associated with food poisoning outbreaks #SciArt #Phage keep tuned for #WorldPhageWeek #WorldPhageDay 22nd October
Loop #inktober2021 #Microber2021 phages are part of the microbial loop which helps bacteria to proliferate, feeding higher tropic levels. Microbes use waste dissolved organic carbon from dead microbes (some killed by phages) to grow and replicate #SciArt #phage Not to scale!
Motility #Microber2021 #inktober2021 Phages have been shown to hitchhike on the flagella of non-host bacteria. Countdown to 22nd October #WorldPhageDay #WorldPhageWeek pubs.acs.org/doi/abs/10.102…
Toxin #Microber2021 #inktober2021 some nasty bacteria infections such as Cholera, Botulism are due to toxins in temperate phages they carry. One reason temperate phages are avoided for phage therapy. 22 Oct #WorldPhageDay #Phage #SciArt Read more: frontiersin.org/articles/10.33…
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