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This October I drew 1 #pdb molecule a day following an official #inktober2021 prompt list. Picking proteins as my theme was risky but rewarding. Lesson learned: proteins are so versatile! See my 31 entries below and let me know your favorite. A thread. @PDBeurope @buildmodels

21/11/02 09:27

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Day 29/31 of #inktober Prompt: PATCH I’m drawing molecules in #pdb Here is Very-Short-PATCH DNA repair endonuclease bound to its reaction product site (1ODG). Next prompt is “Slither” and I would love pdb nominations! @PDBeurope @buildmodels #pdbart #DNA

21/10/31 11:07

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Day 28/31 of #inktober I’m drawing molecules in #pdb this month Prompt CRISP So many people nominated CRISPR Cas9 for this prompt. Here is DNA and guide RNA from pdb 6vpc Next prompt is “patch” and I would love pdb nominations @PDBeurope @buildmodels @takarginov @LindorffLarsen

21/10/31 03:43

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Day 27/31 of #Inktober This month I draw proteins in #pdb Prompt: Spark Firefly Luciferase (4G36) was nominated by @LightUpScience The sparkling lights of fireflies are caused by #luciferase enzyme. pdb101.rcsb.org/motm/78 @AMGulick_Lab @PDBeurope @buildmodels

21/10/29 13:30

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Day 26/31 I’m featuring molecules in #pdb this #inktober Prompt: “Connect” Here is ubiquitin (1UBQ). I could not skip this classic! It connects to its targets, it connects to itself, it connects molecules that otherwise would not find each other… @PDBeurope @PDBeurope

21/10/28 13:36

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Day 25/31 of #inktober Prompt Splat I’m featuring molecules in #PDB SEA domain of mucin 1 (pdb 2ACM). Mucins provide framework of the mucus fluid, which protects all mucosal epithelial surfaces. I imagine it’s pretty slimy and probably lands with a splat! @buildmodels @PDBeurope

21/10/27 13:43

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Day 24/31 of #inktober I’m drawing molecules in #pdb Prompt: extinct Here is hemoglobin of wooly mammoth (3VRE) Next prompt is “splat” and I would love pdb suggestions! @buildmodels @PDBeurope

21/10/26 23:00

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Day 23/31 Prompt LEAK Pdb 6poj I’m drawing molecules in #pdb this #inktober Here is Human aquaporin 1. The first discovered selective water channel present in lipid membranes of cells. Love #NMR ensembles. Next prompt: EXTINCT. Send your suggestions! @PDBeurope @buildmodels

21/10/26 12:15

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Day 22/31 This #inktober I’m drawing molecules in #pdb Prompt: “OPEN” Pdb:4BTF Structure of Pseudokinase MLKL is a special request by @pseudokinase! Next prompt is “leak” and I would love pdb suggestions. @PDBeurope @buildmodels @inktober

21/10/23 14:01

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Day 21/30 This #inktober I’m drawing molecules in #pdb Prompt: FUZZY Pdb: 2JU4 Some proteins need to remain disordered to function Here is fuzzy structural ensemble of the gamma subunit of cGMP phosphodiesterase #NMR @PDBeurope @buildmodels @inktober #pdbart #inktober2021fuzzy

21/10/22 13:01

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Day 20/31 I draw molecules in #pdb this #inktober Prompt: SPROUT Pdb: 1LR5 Nominated by @DaveASci Here is Auxin-Binding Protein 1. It recognizes plant hormone Auxin and regulates plant growth. Next prompt is FUZZY and I would love your pdb nominations! @PDBeurope @buildmodels

21/10/21 12:05

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Day 19/31 This #inktober I’m drawing molecules from #pdb. Prompt “LOOP” Pdb: 1MM5 #NMR structure of the outer membrane enzyme PagP. Next prompt is: SPROUT, and I would love pdb suggestions. @PDBeurope @buildmodels #pdbart

21/10/20 13:06

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Day 18/31 #pdb #inktober Prompt “Moon” There are no proteins on the Moon but here is a moon jelly (Aurelia Aurita) and its protein aurelin (2LG4) that has antimicrobial properties. @inktober ⁦@buildmodels⁩ ⁦@PDBeurope⁩

21/10/19 13:44

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Day 16/31 of #inktober Prompt: COMPASS #Pdb: 6PU0 Pigeon’s compass is a light-dependent magnetosensor CRY4. CRY molecules help migratory birds navigate using the Earth's magnetic field. @buildmodels @buildmodels #pdbart @dsgoodsell #inktober2021compass

21/10/18 12:55

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Day 14/31 I’m doing #inktober drawing molecules from #pdb Today’s prompt is “TICK” Here is Ixolaris, a protein from tick saliva that prevents blood coagulation after the bite. Pdb: 6NAN Next prompt is “helmet” and I would love pdb suggestions! @buildmodels @PDBeurope #pdbart

21/10/15 13:32

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Day 13/31 (symmetry!) Prompt “Roof” I am doing science #inktober featuring molecules in #pdb Here is a special request from @Nancy_Jaiswal23. HU protein (Histone like protein-DNA binding) from Mycobacterium tuberculosis Pdb: 4DKY @buildmodels @inktober #pdbart @PDBeurope

21/10/14 12:54

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Day 12 of #inktober Prompt “stuck” #pdb 6Y1A Sometimes proteins get stuck to each other and form highly regular amyloid structures instead of folding into their native shape. Here are amyloids from pancreatic islets that may cause type2 diabetes. @buildmodels @PDBeurope #cryoem

21/10/13 13:41

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Day 11/31 Prompt “sour” I’m featuring molecules in #pdb for this year’s #inktober Here is Curculin, which has an intriguing property of modifying sour taste into sweet taste. #pdbart @buildmodels @PDBeurope

21/10/12 12:43

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Day 10/31 Prompt “Pick” I’m doing #inktober featuring molecules in the #pdb I picked some pdb flowers (1HTN and 1AQ5) for my mom today. Happy birthday mom! Next prompt is “sour” and I would love pdb suggestions. @inktober #NMR @dsgoodsell @buildmodels #inktober2021pick

21/10/11 11:06

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Day 9/31 Prompt “Pressure” I’m doing #inktober featuring molecules in the #pdb This SH3 domain from Fyn protein has been pressurized to learn about its folding pathway. @inktober #NMR @dsgoodsell @buildmodels @ReidAlderson

21/10/10 12:32

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Day 8/31 Prompt “Watch” I am doing science #inktober featuring molecules in #pdb Here is PAS-A domain of circadian clock protein CLOCK (6QPJ), a part of our time-keeping system. Next up is “pressure”, and I would love pdb suggestions. @buildmodels @inktober #Sciartober

21/10/09 12:13

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Day 7/31 Prompt “FAN” I am doing science #inktober featuring molecules in #pdb Here is a molecule of Keap1 (pdb 1X2J) that forms such a perfect 6-blade propeller! Next up is “watch”, and I would love pdb suggestions. @buildmodels @dsgoodsell @inktober #Sciartober @PDBeurope

21/10/08 13:39

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Day 6/31 Prompt SPIRIT I am doing science #inktober featuring molecules in #pdb Here is a structure of alcohol dehydrogenase ADH1A (pdb 1HSO) that detoxifies alcohol we drink and helps up enjoy our spirits! pdb101.rcsb.org/motm/13 @buildmodels @dsgoodsell @inktober #Sciartober

21/10/07 13:38

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Day 5/31 Prompt “raven” I am doing science #inktober featuring molecules in #pdb Here is a structure a sea raven protein SRAFP (2AFP). It serves as an antifreeze and protects fish from freezing in icy water. @buildmodels @dsgoodsell @inktober #Sciartober

21/10/06 11:31

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Day 4/31 Prompt “knot” I will be doing science #inktober featuring molecules in #pdb Here is a structure of MJ0366. One of a few curious proteins that fold into a knot (2EFV). How do they do it is still a mystery. Next up is “raven” @buildmodels @dsgoodsell @inktober #Sciartober

21/10/05 11:33