#Microber2021 31: MONSTROUS Monsters aren’t always made up, sometimes just spectres from the past. Variola virus caused Smallpox, a terrible disfiguring & often fatal disease. It was eradicated in 1980, but is still scary today. #Inktober2021 #SciArt #PathogenPortraits #SciComm
#Microber2021 29: COLONY All my #PathogenPortraits have too many eyes, but Edwardsiella tarda colonies actually look like googly eyes when grown on the selective ET agar! In other news, E. tarda is mostly a nasty fish tummy bug... #Inktober2021 #SciArt #SciComm
#Microber2021 28: ADHESION Infectious disease can be caused by mere stickiness, as with misfolded Prion proteins. We all have Prions, but if infectious misfolded Prions stick to them, they mis-fold too & the stickiness spreads. #Inktober2021 #SciArt #PathogenPortraits #SciComm
#Microber2021: UPDATE 18 delectable #PathogenPortraits for your pleasure and/or horror! #SciArt #inktober2021
#Microber2021 27: STRAIN Strains have different properties. Asian lineage strains of Zika virus are associated with birth defects, neurological problems & epidemics, but African lineage strains of Zika virus don't seem to be. #Inktober2021 #SciArt #PathogenPortraits #SciComm
#Microber2021 26: COMPETITION Dengue fever virus has 5 serotypes that compete for hosts. Primary infection with 1 makes further infection with another much more dangerous. So it’s a real killer competition! #Inktober2021 #SciArt #PathogenPortraits #SciComm
#Microber2021 25: TRANSPOSON Also known as jumping genes, they’re a handy tool in a many pathogen's toolkit. Transposons give Cryptococcus neoformans the genetic room it needs to adapt & resist antibiotics during infection. #Inktober2021 #SciArt #PathogenPortraits #SciComm
#Microber2021 24: ZOONOTIC Sometimes we're incidental hosts to pathogens. Ebolaviruses mostly infect non-human primates & bats. Our Ebola outbreaks start w. a spillover from these animals, before human to human spread takes over #Inktober2021 #SciArt #PathogenPortraits #SciComm
#Microber2021 23: ANTIBIOTIC We REALLY need new antibiotics for Klebsiella pneumoniae. It’s a deadly hospital-acquired opportunist with many modes of antibiotic resistance that it can share easily with other pathogens. #Inktober2021 #SciArt #PathogenPortraits #SciComm
#Microber2021 22: PERSISTENCE Treponema p. pallidum has been causing syphilis for >5 centuries. This persistent chap can establish lifelong latency, with tertiary symptoms starting up to 45 years after initial infection. #Inktober2021 #SciArt #PathogenPortraits #SciComm
#Microber2021 21: PLASMID Some pathogens need a plasmid to cause disease, like Agrobacterium tumifaciens. Without the tumour-inducing Ti plasmid, it can’t cause crown gall disease in plants. #Inktober2021 #SciArt #PathogenPortraits #SciComm
#Microber2021 20: LUMINESCENCE Yes, there are luminescent pathogens too... Vibrio harveyi causes luminescent vibriosis in farmed shrimp. This may involve widespread necrosis in their appendages, but what a pretty colour! #Inktober2021 #SciArt #PathogenPortraits #SciComm
#Microber2021 19: SECRETION A lot of viruses, like Influenza A, leave their host cells by secretion, in a process called ‘budding’. It helps them form complete virus particles by using host cell membranes. #Inktober2021 #SciArt #PathogenPortraits #SciComm
#Microber2021 18: MOTILITY Proteus is a catheter opportunist with a bullseye motility pattern, due to cycling btw vegetative & swarmer states. A switch to swarming causes massive elongation, many more flagella & all the nasties! #Inktober2021 #SciArt #PathogenPortraits #SciComm
#Microber2021 17: SWIMMING Aeromonas have polar #flagella for swimming motility and lateral flagella for swarming motility. Both are involved in sticking to host cells and setting up shop, but not at the same time! #Inktober2021 #SciArt #PathogenPortraits #scicomm
#Microber2021 16: EXTREMOPHILE Extremophiles have pathogens too! His1 is a halovirus that infects Haloarcula hispanica, an archaeon that grows in 2-4.5M NaCl. His1 can handle all that salt, but unlike its host, doesn’t need it. #Inktober2021 #SciArt #PathogenPortraits #SciComm
#Microber2021 15: TOXIN Clostridium tetani makes tetanus toxin. It causes a rigid paralysis by blocking the action of inhibitory neurons, preventing muscle relaxation. #Inktober2021 #SciArt #PathogenPortraits #SciComm
#Microber2021 14: CHEMOTAXIS Helicobacter uses chemotaxis to swim towards some tasty sugars on the lining of the stomach, and finds its home there for life #Inktober2021 #SciArt #PathogenPortraits #SciComm
#Microber2021 12: DIVISION In their infectious form, these brain-eating amoebae can divide without breaking up their nuclear membrane, in a process called promitosis. #Inktober2021 #SciArt #PathogenPortraits #SciComm
#Microber2021 12: WALL Sometimes it’s the wall that’s pathogenic. In the blood, Neisseria meningitidis can release vesicles made of outer membrane endotoxins, causing immune cascades that can be fatal. #Inktober2021 #SciArt #PathogenPortraits #SciComm
#Microber2021 11: STREAKING Legionella spreads in the air from badly maintained cooling towers. Streaking clinical samples onto yeast charcoal agar + Cysteine helps identify legionella as the cause of pneumonia outbreaks. #Inktober2021 #SciArt #PathogenPortraits #scicomm
#Microber2021 10: DEFENCE As their defence, Bordetalla pertussis attacks our immune defences in the lungs, so the airways don’t produce mucus. This causes the coughs to make a characteristic whooping sound #Inktober2021 #SciArt #PathogenPortraits #SciComm
#Microber2021: UPDATE 9 #PathogenPortraits down, 22 to go! (seeing it all together helps motivate me at this point to keep going...) #inktober2021 #daily #sciart #microbiology
#Microber2021 9: NICHE Mycobacterium leprae can only replicate in human & armadillo hosts after wholesale genome degradation... but only in their extremities, where it’s a bit cooler! #Inktober2021 #SciArt #PathogenPortraits
#Microber2021 8: QUORUM SENSING. Candida albicans grows in 2 forms; both yeast & hyphae are important during infection & quorum sensing is one way Candida is able to switch between the two. #Inktober2021 #SciArt #PathogenPortraits
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